PMID- 31442638
OWN - NLM
STAT- MEDLINE
DCOM- 20200124
LR  - 20200124
IS  - 1878-8769 (Electronic)
IS  - 1878-8750 (Linking)
VI  - 132
DP  - 2019 Dec
TI  - Anxiety and Depression in Patients with Intracranial Arachnoid Cysts-A Prospective 
      Study.
PG  - e645-e653
LID - S1878-8750(19)32213-2 [pii]
LID - 10.1016/j.wneu.2019.08.058 [doi]
AB  - BACKGROUND: Arachnoid cysts yield cognitive deficits that are normalized after 
      surgical cyst decompression. OBJECTIVE: The present study aimed to investigate 
      whether arachnoid cysts also affect symptoms of anxiety and depression, and if 
      surgical cyst decompression leads to reduction of these symptoms. METHODS: 
      Twenty-two adult patients (13 men and 9 women) with symptomatic temporal or frontal 
      cysts were included in this questionnaire (Hospital Anxiety and Depression Scale 
      [HADS])-based prospective study. The mean time between answering the preoperative 
      questionnaire and surgery was 37 days. The patients answered the same HADS 
      questionnaire 3-6 months postoperatively. RESULTS: Preoperatively, both patients 
      with frontal (N = 4) and patients with temporal (N = 18) cyst had higher mean HADS 
      anxiety scores than those found in the general population. For patients with 
      temporal cyst, there was a significant or near-significant difference in anxiety and 
      depression scores and the combined scores between those with right-sided cysts and 
      those with left-sided cysts. Postoperatively, the HADS scores normalized and were no 
      longer different from those of the general population. The difference in scores 
      between patients with right and left temporal cyst also disappeared. CONCLUSIONS: 
      Patients with arachnoid cyst have higher levels of anxiety and depression than do 
      the general population and these scores were normalized after decompressive cyst 
      surgery. We further found a hemispheric asymmetry: patients with a right temporal 
      cyst showed higher anxiety, depression, and combined scores than did patients with a 
      left temporal cyst. Also, this disparity normalized after cyst decompression. Thus, 
      arachnoid cysts seem to affect not only cognition but also the level of affective 
      symptoms.
CI  - Copyright © 2019 Elsevier Inc. All rights reserved.
FAU - Gjerde, Priyanthi B
AU  - Gjerde PB
AD  - Department of Clinical Medicine K1, University of Bergen, Bergen, Norway; The 
      Norwegian Centre for Mental Disorders Research (NORMENT) and the K.G. Jebsen Centre 
      for Psychosis Research, Department of Clinical Medicine K2, University of Bergen, 
      Bergen, Norway.
FAU - Litleskare, Sverre
AU  - Litleskare S
AD  - Department of Clinical Medicine K1, University of Bergen, Bergen, Norway; Research 
      Unit for General Practice, Uni Research Health, Bergen, Norway.
FAU - Lura, Njål Gjærde
AU  - Lura NG
AD  - Department of Clinical Medicine K1, University of Bergen, Bergen, Norway; Department 
      of Radiology, Haukeland University Hospital, Bergen, Norway.
FAU - Tangen, Tone
AU  - Tangen T
AD  - Department of Clinical Medicine K1, University of Bergen, Bergen, Norway; Section of 
      Psychiatry, Haukeland University Hospital, Bergen, Norway.
FAU - Helland, Christian A
AU  - Helland CA
AD  - Department of Clinical Medicine K1, University of Bergen, Bergen, Norway; Department 
      Neurosurgery, Haukeland University Hospital, Bergen, Norway.
FAU - Wester, Knut
AU  - Wester K
AD  - Department of Clinical Medicine K1, University of Bergen, Bergen, Norway; Department 
      Neurosurgery, Haukeland University Hospital, Bergen, Norway. Electronic address: 
      kgwe@helse-bergen.no.
LA  - eng
PT  - Journal Article
DEP - 20190820
PL  - United States
TA  - World Neurosurg
JT  - World neurosurgery
JID - 101528275
SB  - IM
MH  - Adult
MH  - Anxiety/*etiology
MH  - Arachnoid Cysts/*complications/psychology/*surgery
MH  - Decompression, Surgical/methods
MH  - Depression/*etiology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neurosurgical Procedures/methods
MH  - Prospective Studies
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Anxiety
OT  - Arachnoid cyst
OT  - Cognition
OT  - Depression
OT  - Frontal lobe
OT  - Temporal lobe
EDAT- 2019/08/24 06:00
MHDA- 2020/01/25 06:00
CRDT- 2019/08/24 06:00
PHST- 2019/08/07 00:00 [received]
PHST- 2019/08/09 00:00 [accepted]
PHST- 2019/08/24 06:00 [pubmed]
PHST- 2020/01/25 06:00 [medline]
PHST- 2019/08/24 06:00 [entrez]
AID - S1878-8750(19)32213-2 [pii]
AID - 10.1016/j.wneu.2019.08.058 [doi]
PST - ppublish
SO  - World Neurosurg. 2019 Dec;132:e645-e653. doi: 10.1016/j.wneu.2019.08.058. Epub 2019 
      Aug 20.